Panama is generally considered safe for tourists who stay in well-known travel areas and use common-sense precautions. Most visitors experience Panama through Panama City, the Panama Canal, Casco Viejo, Boquete, Bocas del Toro, San Blas/Guna Yala, Pacific beaches, and organized tours without major issues.
That said, Panama is not risk-free. The U.S. Department of State currently advises travelers to exercise increased caution in Panama due to crime and possible civil unrest, and specifically says not to travel to parts of the Darién Region and parts of the Mosquito Gulf. Petty theft, pickpocketing, purse snatching, and scams can happen in busy areas, public transportation zones, nightlife areas, malls, and tourist sites.
In Panama City, tourists should be more careful in or near areas with higher crime levels, especially if they are unfamiliar with the city. The UK travel advice highlights areas such as San Miguelito, El Chorrillo, Río Abajo, 24 de Diciembre, Santa Ana, and Juan Díaz as places with higher crime levels. This does not mean every part of the city is dangerous, but it does mean visitors should plan transportation carefully and avoid wandering into unknown areas at night.
For most tourists, the safest approach is simple: use Uber or trusted transport, keep valuables out of sight, avoid walking alone late at night in poorly lit areas, use ATMs inside banks or malls, follow local news during protests, and book adventure activities with reputable guides. In natural areas, safety also depends on the activity. Beaches can have strong currents, and hiking areas such as Boquete may have poorly marked trails, so guided tours are recommended for unfamiliar routes.
Overall, Panama is a practical and rewarding destination for tourists, but it is best enjoyed with awareness. It is safer when travelers stay in established areas, avoid remote high-risk zones, protect their belongings, and use trusted local guidance.